Growing up may be a rough road, and there is no exception for Riley, who is uprooted from her life when her daddy starts a brand new job at San Francisco. Riley's guiding emotions-- Joy, Fear, Anger, Disgust and Sadness--live in Headquarters, the hands centre in Riley's mind, where they help counsel her through regular activity and attempts to keep things positive, however also the emotions conflict how to navigate a new city, school and house.