Gabriel Cash and ray Tango are narcotics detectives who can not stand each other. Crime Lord Yves Perret, angry at the loss of income which Tango and Cash have compelled him, frames the two for murder. Caught on the scene of the offense with the murder weapon, the two have no alibi. Thrown into prison with most of the offenders they helped convict, it appears that they are going to have to trust one another if they are supposed to clear their names and also capture the Perret.