The Cassandra Crossing can be an all-star disaster spectacular telling of 1, 000 doomed passengers trapped aboard a plague-infested train's frightening odyssey. A terrorist exposes into the disorder and infected by a virus planks the Stockholm into Geneva Express. Colonel Mackenzie (Burt Lancaster) is called in to handle the problem and finds out Dr. Chamberlain (Richard Harris) who is onboard the train. Where it will plunge into oblivion mackenzie decides to reroute the train. But passengers begin to recuperate and Chamberlain must race against the time to disconnect those cars.