Extreme athlete turned government operative Xander Cage arrives of self imposed exile, thought to be long dead, and is put to a collision course with mortal alpha warrior Xiang and his team at a race to recover a menacing and seemingly unstoppable weapon known as Pandora's Box. Recruiting a all-new set of cohorts, Xander finds himself enmeshed in a deadly conspiracy which points to collusion at the highest levels of world governments.