Set in downtown New York in 1900,'The Knick' is centered on the revolutionary surgeons and the Knickerbocker Hospital, physicians and staff who work there, pushing the boundaries of medicine in a time of zero antibiotics and astonishingly higher mortality rates.John Thackery can be an excellent surgeon new methods within the area, despite his obsession with alcoholism. He also leads a team of health practitioners for example his protégé Dr. Everett Gallinger. The young Dr. Bertie Chickering Jr. and Dr. Algernon Edwards, a promising surgeon who has recently been thrust up on him. The cast of characters at the hospital also includes Captain August Robertson, Cornelia Robertson, the girl of its benefactor. Creek driver Tom Cleary. Lucy Elkins. A nurse out of the nation. The crooked hospital administrator Herman Barrow. And Sister Harriet.