In the year 1500, Duke Cesare Borgia has the ambitious goal of marrying his sister off to the heir apparent of Ferrara. This goal, however, stands in the way of his conquest of central Italy. Andrea Orsini, his sister's boyfriend and someone who is almost as unscrupulous as the man himself, is the one he entrusts with this sensitive assignment. Along the way, Orsini encounters Camilla Verano, who is the wife of the count of Citta' del Monte. Orsini's feelings for Camilla threaten to turn him against his lethal lord, whom no one betrays twice...